A young woman studying the habits of webcam chat users from the apparent safety of her apartment witnesses a brutal murder online and is quickly immersed in a nightmare in which she and her loved ones are targeted for the same grisly fate as the first victim.

An American girl, Isabella, sets out to make a documentary to understand what happened to her mother who murdered three clergy people. She was not convicted due to insanity and was sent to a mental hospital in Italy. Isabella meets with some priests in Italy who explain that her mother's condition may not be medical, but could be an extra-human possession.